Synthesis of Flavonoids or Other Nature-Inspired Small Molecules

Nature-Inspired Synthesis of Rational Protocols

Rational cryptography is an emerging field which combines aspects traditionally related to security with concepts described in economic theoretical frameworks. For example, it applies game theory concepts to address security problems arising when executing cryptographic protocols. The aim is to replace the assumption of a worst–case attacker by the notion of rational agents that try to maximize...

Nature-inspired total synthesis of (-)-fusarisetin A.

A concise, protecting group-free total synthesis of (-)-fusarisetin A (1) was efficiently achieved in nine steps from commercially available (S)-(-)-citronellal. The synthetic approach was inspired by our proposed biosynthesis of 1. Key transformations of our strategy include a facile construction of the decalin moiety that is produced via a stereoselective IMDA reaction and a one-pot TEMPO-ind...

BBO Comparison with other Nature Inspired Algorithms to Resolve Mixels

Remote sensing is defined as a technique for acquiring the information about an object without making physical contact with that image via remote sensors. But the major problem of remotely sensed images is mixed pixel which always degrades the image quality. In this paper we attempted to present an approach for resolving the mixed pixels by using optimization/ Evolutionary algorithm i.e. Biogeo...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Design, Synthesis and Evaluation of Substituted Aryl-2-Nitrovinyl Derivatives as Small Molecules Proteasome Inhibitors

Based on the existing structure activity relationship for proteasome inhibitors, a number of substituted aryl-2-nitrovinyl derivatives have been synthesized as Michael acceptor and their cytotoxicity and proteasome inhibitory effects were evaluated on two cancer cell lines. Compound 2d exhibited IC50 values of 0.71 and 17.79 μM comparable to bortezomib against MCF-7 and PC-3, respectively. The ...